• Open Access

Murine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function

Authors

  • Ying Y. Hey,

    1. Research School of Biology, The Australian National University, Canberra, Australia
    Search for more papers by this author
  • Helen C. O'Neill

    Corresponding author
    1. Research School of Biology, The Australian National University, Canberra, Australia
    • Correspondence to: Prof. Helen O'NEILL, Research School of Biology, Building #134 Linnaeus Way, The Australian National University, Canberra, ACT 0200, Australia.

      Tel.: +61 2 6125 4720

      Fax: +61 2 6125 0313

      E-mail: Helen.ONeill@anu.edu.au

    Search for more papers by this author

Abstract

The spleen contains multiple subsets of myeloid and dendritic cells (DC). DC are important antigen presenting cells (APC) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naïve T cells. However, DC are a heterogeneous population and each subset differs subtly in phenotype, function and location. Similarly, myeloid cell subsets can be distinguished which can also play an important role in the regulation of immunity. This review aims to characterize splenic subsets of DC and myeloid cells to better understand their individual roles in the immune response.

Ancillary