1582-4934/asset/olbannerleft.gif?v=1&s=9ac4fbc1c8dd6b354380356601e09fc12424db35)
1582-4934/asset/olbannerright.gif?v=1&s=cd3126c456d5857b7dbedcf7ab88bbd934f98dcc)
Original Article
You have open access to this content
Characterization of the tissue-level Ca2+ signals in spontaneously contracting human myometrium
Article first published online: 13 DEC 2012
DOI: 10.1111/j.1582-4934.2012.01626.x
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
Total views since publication: 148
Additional Information
How to Cite
Bru-Mercier, G., Gullam, J. E., Thornton, S., Blanks, A. M. and Shmygol, A. (2012), Characterization of the tissue-level Ca2+ signals in spontaneously contracting human myometrium. Journal of Cellular and Molecular Medicine, 16: 2990–3000. doi: 10.1111/j.1582-4934.2012.01626.x
Publication History
- Issue published online: 13 DEC 2012
- Article first published online: 13 DEC 2012
- Accepted manuscript online: 4 SEP 2012 10:41AM EST
- Manuscript Accepted: 28 AUG 2012
- Manuscript Received: 17 APR 2012
Funded by
- BBSRC. Grant Number: BB/D016630/1
- Reproductive Health Biomedical Research Unit
- University Hospital Coventry and Warwickshire
- Abstract
- Article
- References
- Cited By
- Cumulative Usage
References
- 1. Cholinergic Mechanisms in Smooth-Muscle. Br Med Bull. 1979; 35: 275–83.
- 2, , , et al. Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels. Physiol Rev. 1998; 78: 811–920.
- 3, . Relationship between electrical and mechanical activity of the isolated term-pregnant human myometrium. Eur J Obstet Gynecol Reprod Biol. 1985; 20: 337–46.
- 4, , , et al. Oxytocin enhances action potentials in pregnant human myometrium - A study with microelectrodes. Am J Obstet Gynecol. 1997; 177: 222–8.
- 5, , , et al. Modification by Magnesium of the Excitatory Effect of Oxytocin in Electrical and Mechanical Activities of Pregnant Human Myometrium. Obst Gynecol. 1990; 76: 183–8.
- 6, , , et al. Contractile activity, membrane potential, and cytoplasmic calcium in human uterine smooth muscle in the third trimester of pregnancy and during labor. Am J Obst Gynecol. 1999; 181: 1445–51.
- 7, , . Gap Junctions - Their Presence and Necessity in Myometrium during Parturition. Science. 1977; 198: 958–60.
- 8, , , et al. Gap junction currents in cultured muscle cells from human myometrium. Am J Obst Gynecol. 1998; 178: 588–93.
- 9, , . Modulation of Cell-to-Cell Coupling between Myometrial Cells of the Human Uterus during Pregnancy. Am J Obst Gynecol. 1992; 167: 472–80.
- 10, , . Invitro Studies on the Control of Human Myometrial Gap-Junctions. Int J Gynecol Obstet. 1987; 25: 241–8.
- 11, , , et al. Tissue-level Ca2+ signalling in human myometrium: a possible role for ICCs. Proc Physiol Soc. 2006; 3: 75–76.
- 12, , , et al. C-kit immunopositive interstitial cells (Cajal-type) in human myometrium. J Cell Mol Med. 2005; 9: 407–20.
- 13, , , et al. Vimentin-positive, c-KIT-negative interstitial cells in human and rat uterus: A role in pacemaking? Biol Reprod. 2005; 72: 276–83.
- 14, . TELOCYTES - a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES. J Cell Mol Med. 2010; 14: 729–40.
- 15, , , et al. Imatinib inhibits spontaneous rhythmic contractions of human uterus and intestine. Eur J Pharmacol. 2006; 546: 177–81.
- 16. Myocytes, myometrium, and uterine contractions. Ann N Y Acad Sci. 2007; 1101: 72–84.
- 17, . Three-dimensional structure of the smooth muscle in the term-pregnant human uterus. Obst Gynecol. 1999; 93: 94–9.
- 18, , . Oxytocin increases the [Ca2+](i) sensitivity of human myometrium during the falling phase of phasic contractions. Am J Physiol. 1999; 276: E345–51.
- 19, , . Activation Properties of Myosin Light-Chain Kinase during Contraction-Relaxation Cycles of Tonic and Phasic Smooth Muscles. J Biol Chem. 1994; 269: 21596–602.
- 20, , , et al. Effect of magnesium sulfate on contractile force and intracellular calcium concentration in pregnant human myometrium. Am J Obstet Gynecol. 2006; 194: 1384–90.
- 21, , , et al. Role of Protein Kinase C alpha in Regulation of [Ca(2+)](I) and Force in Human Myometrium. Reprod Sci. 2009; 16: 71–9.
- 22, , , et al. The effects of inhibiting myosin light chain kinase on contraction and calcium signalling in human and rat myometrium. Pflugers Arch. 2000; 440: 315–21.
- 23, , , et al. Calcium-independent force production by human myometrium? Br J Obstet Gynaecol. 2000; 107: 815–6.
- 24, . Intra- and intercellular calcium waves in cultured human myometrium. J Muscle Res Cell Motil. 1996; 17: 349–55.
- 25, . Stimulation of intracellular Ca2+ oscillations by diacylglycerol in human myometrial cells. Cell Calcium. 2004; 36: 157–64.
- 26, , , et al. Temporal and spatial variations in spontaneous Ca events and mechanical activity in pregnant rat myometrium. Eur J Obstet Gynecol Reprod Biol. 2009; 1445: s25–32.
- 27, , , et al. Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophys J. 2000; 78: 2655–67.
- 28, , , et al. Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium. J Physiol (Lond). 2007; 581: 915–26.
- 29. Tissue-level signaling and control of uterine contractility: the action potential-calcium wave hypothesis. J Soc Gynecol Investig. 2000; 7: 146–52.
- 30, , , et al. The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil. Drug Metab Dispos. 2008; 36: 1291–9.
- 31, , , et al. NNC 55-0396 [(1S, 2S)-2-(2-(N-[(3-benzimidazol-2-yl) propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004; 309: 193–9.
- 32, , , et al. A mathematical model of uterine dynamics and its application to human parturition. Acta Biotheor. 2000; 48: 95–105.
- 33. A computer model of uterine contractions based on action potential propagation and intercellular calcium waves. Obst Gynecol. 1997; 89: 604–8.
- 34, , , et al. Identification and electrophysiological characteristics of isoforms of T-type calcium channel Ca(v)3.2 expressed in pregnant human uterus. Cell Physiol Biochem. 2005; 16: 245–54.
- 35, , , et al. Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res. 2005; 96: 864–72.
- 36, , . A description of Ca(2+) channels in human detrusor smooth muscle. Bju Int. 2003; 92: 476–82.
- 37, , . Role of T-type Ca(2+) Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle. Korean J Physiol Pha. 2009; 13: 241–9.