Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat

Authors

  • Baoyin Zhao,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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    • These authors contributed equally to this work.
  • Shang Chen,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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    • These authors contributed equally to this work.
  • Juanjuan Liu,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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  • Ziqiang Yuan,

    1. Department of Molecular Genetics, Albert Einstein College of Medicine, New York, USA
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  • Xufeng Qi,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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  • Junwen Qin,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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  • Xin Zheng,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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  • Xiaotao Shen,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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  • Yanhong Yu,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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  • Thomas J. Qnin,

    1. Department of Molecular Genetics, Albert Einstein College of Medicine, New York, USA
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  • John Yeuk-Hon Chan,

    1. Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    2. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    3. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    4. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
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  • Dongqing Cai

    Corresponding author
    1. Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China
    2. International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China
    3. Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China
    • Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
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Correspondence to: Dongqing CAI, Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou 510632, China.

Tel. +86-20-85222711

Fax +86-20-85222711

E-mail: tdongbme@jnu.edu.cn

Abstract

Recently, cardiac telocytes were found in the myocardium. However, the functional role of cardiac telocytes and possible changes in the cardiac telocyte population during myocardial infarction in the myocardium are not known. In this study, the role of the recently identified cardiac telocytes in myocardial infarction (MI) was investigated. Cardiac telocytes were distributed longitudinally and within the cross network of the myocardium, which was impaired during MI. Cardiac telocytes in the infarction zone were undetectable from approximately 4 days to 4 weeks after an experimental coronary occlusion was used to induce MI. Although cardiac telocytes in the non-ischaemic area of the ischaemic heart experienced cell death, the cell density increased approximately 2 weeks after experimental coronary occlusion. The cell density was then maintained at a level similar to that observed 1–4 days after left anterior descending coronary artery (LAD)-ligation, but was still lower than normal after 2 weeks. We also found that simultaneous transplantation of cardiac telocytes in the infarcted and border zones of the heart decreased the infarction size and improved myocardial function. These data indicate that cardiac telocytes, their secreted factors and microvesicles, and the microenvironment may be structurally and functionally important for maintenance of the physiological integrity of the myocardium. Rebuilding the cardiac telocyte network in the infarcted zone following MI may be beneficial for functional regeneration of the infarcted myocardium.

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