Enteric neurons show a primary cilium

Authors

  • Mª José Luesma,

    Corresponding author
    1. Aragon Health Research Institute (IIS Aragón), Scientific Research Centre of Aragón, Zaragoza, Spain
    • Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
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  • Irene Cantarero,

    1. Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
    2. Aragon Health Research Institute (IIS Aragón), Scientific Research Centre of Aragón, Zaragoza, Spain
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  • Tomás Castiella,

    1. Aragon Health Research Institute (IIS Aragón), Scientific Research Centre of Aragón, Zaragoza, Spain
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  • Mario Soriano,

    1. Príncipe Felipe Research Centre, Cell Biology Laboratory, Valencia, Spain
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  • José Manuel Garcia–Verdugo,

    1. Príncipe Felipe Research Centre, Cell Biology Laboratory, Valencia, Spain
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  • Concepción Junquera

    1. Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
    2. Aragon Health Research Institute (IIS Aragón), Scientific Research Centre of Aragón, Zaragoza, Spain
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Correspondence to: Prof. Mª José LUESMA, Prof. Concepción JUNQUERA, Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Domingo Miral s/n 50009, Zaragoza, Spain.

Tel.: +34-976-761684

Fax: +34-976-761754

E-mails: mjluesma@unizar.es; cjunquer@unizar.es

Abstract

The primary cilium is a non-motile cilium whose structure is 9+0. It is involved in co-ordinating cellular signal transduction pathways, developmental processes and tissue homeostasis. Defects in the structure or function of the primary cilium underlie numerous human diseases, collectively termed ciliopathies. The presence of single cilia in the central nervous system (CNS) is well documented, including some choroid plexus cells, neural stem cells, neurons and astrocytes, but the presence of primary cilia in differentiated neurons of the enteric nervous system (ENS) has not yet been described in mammals to the best of our knowledge. The enteric nervous system closely resembles the central nervous system. In fact, the ultrastructure of the ENS is more similar to the CNS ultrastructure than to the rest of the peripheral nervous system. This research work describes for the first time the ultrastructural characteristics of the single cilium in neurons of rat duodenum myenteric plexus, and reviews the cilium function in the CNS to propose the possible role of cilia in the ENS cells.

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