DEVELOPMENT OF ANTICONVULSANT OSTEOMALACIA IN EPILEPTIC PATIENTS ON PHENYTOIN TREATMENT
Article first published online: 29 JAN 2009
Acta Neurologica Scandinavica
Volume 50, Issue 4, pages 527–532, August 1974
How to Cite
Rødbro, P., Christiansen, C. and Lund, M. (1974), DEVELOPMENT OF ANTICONVULSANT OSTEOMALACIA IN EPILEPTIC PATIENTS ON PHENYTOIN TREATMENT. Acta Neurologica Scandinavica, 50: 527–532. doi: 10.1111/j.1600-0404.1974.tb02798.x
- Issue published online: 29 JAN 2009
- Article first published online: 29 JAN 2009
- Received March 6, 1974.
In 151 epileptic patients, who had been treated with phenytoin for from 3 months to 31 years, the three indices of anticonvulsant osteomalacia: Serum calcium, serum alkaline phosphatase, and bone mineral content were studied to find the relation between the pathological changes and the duration of phenytoin treatment. The results indicate that anticonvulsant osteomalacia sets in quite early after institution of phenytoin treatment, and is kept at a constant level thereafter. If epileptics should have prophylactic vitamin D treatment, the extra supply of vitamin D probably should he given from the beginning of the anticonvulsant therapy.