Serum lipids and anticonvulsants


Peter Berlit, M.D., Neurologische Universitatsklinik, VoBstr. 2, D-6900 Heidelberg, F.R.G.


The serum lipid levels of 200 epileptics (aged 20 to 40 years) undergoing long-term treatment with anticonvulsants were measured and compared with the levels of a normal population of the same age. The epileptics had higher serum lipid levels (especially of apolipoprotein B and HDL-cholesterol) but no higher incidence of hyperlipemias. A correlation between LDL-cholesterol and vitamin E has been found in epileptics, but it was not as significant as in normals. In male epileptics, positive correlations between the average daily dose of anticonvulsants (especially of those with a well-known enzyme-inducing effect) and triglycerides, cholesterol and LDL-cholesterol were found; in females there were no significant correlations.