Weight gain during treatment with valproate
Article first published online: 29 JAN 2009
Acta Neurologica Scandinavica
Volume 70, Issue 2, pages 65–69, August 1984
How to Cite
Dinesen, H., Gram, L., Andersen, T. and Dam, M. (1984), Weight gain during treatment with valproate. Acta Neurologica Scandinavica, 70: 65–69. doi: 10.1111/j.1600-0404.1984.tb00804.x
- Issue published online: 29 JAN 2009
- Article first published online: 29 JAN 2009
- Accepted for publication March 30, 1984
- Side effects;
- weight gain
Abstract– An analysis was made of weight changes during treatment with valproate in 63 adult epileptic patients.
36 patients (57%) gained more than 4 kg in weight during treatment, while 27 patients (43%) were stable in weight with weight changes of less than ± 4 kg.
There were no significant differences between weight gainers and weight-stable patients with regard to age, sex, pretreatment overweight, duration of treatment, dosage or serum levels of valproate. From structured patient interviews, it appeared that the 2 groups of patients differed only insignificantly with regard to appetite, thirst and familial predispositions to obesity and diabetes. Consequently, no factors predictive for weight gain could be outlined. Presumable pathogenic mechanisms of importance are discussed.