Get access

Midbrain hypometabolism as early diagnostic sign for progressive supranuclear palsy

Authors

  • M. Mishina,

    1. The Department of Neurology, Neurological Institute, Nippon Medical School Chiba-Hokusoh Hospital, Inba-gun, Chiba
    2. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi–ku, Tokyo
    3. The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo
    Search for more papers by this author
  • K. Ishii,

    1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi–ku, Tokyo
    Search for more papers by this author
  • K. Mitani,

    1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi–ku, Tokyo
    Search for more papers by this author
  • M. Ohyama,

    1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi–ku, Tokyo
    2. The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo
    Search for more papers by this author
  • M. Yamazaki,

    1. The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo
    2. Geriatric Neuroscience Research Group, Tokyo Metropolitan Institute of Gerontology, Itabashi–ku, Tokyo
    Search for more papers by this author
  • K. Ishiwata,

    1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi–ku, Tokyo
    Search for more papers by this author
  • M. Senda,

    1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi–ku, Tokyo
    2. The Department of Neurosurgery, Neurological Institute, Nippon Medical School Chiba-Hokusoh Hospital, Inba-gun, Chiba
    Search for more papers by this author
  • S. Kobayashi,

    1. Institute of Biomedical Research and Innovation, Kobe–shi, Hyogo
    Search for more papers by this author
  • S. Kitamura,

    1. The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo
    2. The Department of Internal Medicine, Nippon Medical School Second Hospital, Kawasaki–shi, Kanagawa, Japan
    Search for more papers by this author
  • Y. Katayama

    1. The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo
    Search for more papers by this author

Masahiro Mishina, Neurological Institute, Nippon Medical School Chiba-Hokusoh Hospital, 1715 Kamagari, Inba-mura, Inba-gun Chiba 270-1694 Japan
Tel.: 81 476 99 1111
Fax: 81 476 99 1908
e-mail: mishina@nms.ac.jp

Abstract

Objective – Progressive supranuclear palsy (PSP) is often misdiagnosed in early phase. The purpose of this study is to investigate the feature of [18F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography images for the early diagnosis of PSP.

Methods – We studied 15 patients with PSP and 16 normal subjects. Using SPM99 and analysis of covariance to eliminate the effect of aging, the differences between PSP and normals were displayed as a statistical map. In the PSP, we also investigated the correlation with duration and with the subscores of Unified Parkinson's Disease Rating Scale.

Results – The glucose metabolism of midbrain was significantly lower in PSP than in normals. However, correlation was not found between the metabolism of midbrain and clinical deterioration.

Conclusions – The statistical map clearly demonstrated the hypometabolism of midbrain in PSP, which is independent of the clinical deterioration. The hypometabolism of midbrain is one of the most promising sign for early diagnosis of PSP.

Ancillary