Increased CSF/serum albumin ratio: a recurrent finding in violent offenders
Article first published online: 2 JUN 2005
Acta Neurologica Scandinavica
Volume 112, Issue 1, pages 48–50, July 2005
How to Cite
Anckarsäter, H., Forsman, A. and Blennow, K. (2005), Increased CSF/serum albumin ratio: a recurrent finding in violent offenders. Acta Neurologica Scandinavica, 112: 48–50. doi: 10.1111/j.1600-0404.2005.00433.x
- Issue published online: 2 JUN 2005
- Article first published online: 2 JUN 2005
- Accepted for publication April 8, 2005
- forensic psychiatry;
- blood–brain barrier;
- cerebrospinal fluid;
- central nervous system;
Objective – To test the hypothesis that cerebrospinal fluid (CSF)/ serum albumin ratios are increased in violent offenders.
Subjects and methods – In a previous study of violent offenders, we found significantly higher CSF/serum album ratios (as a sign of increased blood–brain barrier permeability) in violent offenders than in healthy controls. For the present replication study, we recruited a new group of 28 violent offenders, aged 45 years or younger, and 20 new control subjects.
Results – The albumin ratio was again significantly higher in the offender group (mean 6.2) than in the control group (mean 4.6) (P = 0.012). Substance abuse or current medication did not appear to explain this finding.
Conclusion – Increased CSF/serum albumin ratios are an unspecific sign of neurological dysfunction in subgroups of violent offenders.