Flow-mediated dilatation and intima-media thickness in patients with lacunar infarctions
Article first published online: 8 MAR 2006
Acta Neurologica Scandinavica
Volume 113, Issue 4, pages 273–277, April 2006
How to Cite
Pretnar-Oblak, J., Sabovic, M., Pogacnik, T., Sebestjen, M. and Zaletel, M. (2006), Flow-mediated dilatation and intima-media thickness in patients with lacunar infarctions. Acta Neurologica Scandinavica, 113: 273–277. doi: 10.1111/j.1600-0404.2006.00578.x
- Issue published online: 8 MAR 2006
- Article first published online: 8 MAR 2006
- Accepted for publication December 13, 2005
- cardiovascular risk factors;
- endothelial function;
- flow-mediated dilatation;
- intima-media thickness;
- lacunar infarction
Objectives – To evaluate systemic endothelial function and atherosclerotic changes in patients with lacunar infarctions (LI) we examined flow-mediated dilatation (FMD) and intima-media thickness (IMT) and compared them to patients with similar risk factors (SR) and healthy controls.
Methods – FMD and IMT were investigated in patients with LI (20 patients, aged 60.9 ± 7.3 years), 21 age- and gender-matched patients with SR and 21 healthy controls.
Results – FMD was more impaired in patients with LI (0.4% ± 5.0%) compared to patients with SR (3.8% ± 4.8%) and healthy controls (7.9% ± 6.0%) (P ≤ 0.01), whereas IMT was similarly thickened in both groups of patients.
Conclusions – We found that patients with LI have a diminished FMD, but a similar IMT, compared to patients with SR. Our results reveal that for a given level of atherosclerosis patients with LI have additional endothelial impairment.