Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis
Article first published online: 21 JUL 2006
Acta Neurologica Scandinavica
Volume 115, Issue 2, pages 109–114, February 2007
How to Cite
Lepej, S. Ž., Mišić-Majerus, L., Jeren, T., Rode, O. D., Remenar, A., Šporec, V. and Vince, A. (2007), Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis. Acta Neurologica Scandinavica, 115: 109–114. doi: 10.1111/j.1600-0404.2006.00726.x
- Issue published online: 24 JUL 2006
- Article first published online: 21 JUL 2006
- Accepted for publication June 21, 2006
- cerebrospinal fluid;
- tick-borne encephalitis
Objectives – The aim of our study was to determine whether cerebrospinal fluid (CSF) of patients with tick-borne encephalitis (TBE) contains CXCL10, CXCL11, p40 subunit of interleukin-12 (IL-12)/IL-23, IL-18 and IL-15. We compared serum and CSF concentrations of CXCL10 and analysed the possible concentration gradient of this chemokine between the periphery and central nervous system.
Materials and methods – The study enrolled 19 TBE patients and 10 patients with non-inflammatory neurological diseases.
Results – CSF of TBE patients contained CXCL10 (median 217 pg/ml), CXCL11 (8.3 pg/ml), p40 subunit of IL-12/IL-23 (38.9 pg/ml), IL-18 (30.1 pg/ml) and IL-15 (5.9 pg/ml). CXCL10 in the CSF of TBE patients was higher compared with serum (median 62 pg/ml, P < 0.001).
Conclusion – CSF of TBE patients contains CXCL10, CXCL11, p40 subunit of IL-12/IL-23, IL-18 and IL-15. Increased CXCL10 concentration in CSF suggests a role for this chemokine in the recruitment of CXCR3-expressing T-cells into the CSF of TBE patients.