Nitric oxide synthase and NMDA receptor expressions in cavernoma tissues with epileptogenesis
Article first published online: 25 JUL 2007
Acta Neurologica Scandinavica
Volume 116, Issue 6, pages 368–373, December 2007
How to Cite
Kamida, T., Takeda, Y., Fujiki, M., Abe, T., Abe, E. and Kobayashi, H. (2007), Nitric oxide synthase and NMDA receptor expressions in cavernoma tissues with epileptogenesis. Acta Neurologica Scandinavica, 116: 368–373. doi: 10.1111/j.1600-0404.2007.00885.x
- Issue published online: 22 AUG 2007
- Article first published online: 25 JUL 2007
- Accepted for publication April 12, 2007
- nitric oxide synthase;
- hemosiderin deposits;
Objectives – To investigate the contribution of nitric oxide (NO) and the glutamate systems to epileptogenicity of cavernoma (CA).
Methods – Using immunohistochemistry we examined NO synthases (NOS; neuronal, inducible and endothelial) and N-methyl-D-aspartate (NMDA) receptor subunits 1(NR1) and 2A/B (NR2A/B) in tissues, with and without hemosiderin deposits, adjacent to CA resected from temporal (seven patients) and frontal (one patient) lobes.
Results – All isoforms of NOS, especially iNOS expression, was significantly upregulated in company with NR2A/B expression, not only in declining neuronal cells but also in reactive astrocytes in the tissue, with hemosiderin deposits, adjacent to CA and moreover the degree of iNOS expression was significantly correlated with seizure frequency.
Conclusions – These preliminary results sustain a speculation that excessive NO may generate in the tissue surrounding CA with repeated microhaemorrhaging and seizures. The neuronal loss and reactive glial proliferation induced by iron or NO may play a role in epileptogenesis.