Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson’s disease – a rCBF scintigraphy study
Article first published online: 10 OCT 2007
Acta Neurologica Scandinavica
Volume 116, Issue 6, pages 347–354, December 2007
How to Cite
Wallin, A., Ekberg, S., Lind, K., Milos, V., Granérus, A.-K. and Granerus, G. (2007), Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson’s disease – a rCBF scintigraphy study. Acta Neurologica Scandinavica, 116: 347–354. doi: 10.1111/j.1600-0404.2007.00887.x
- Issue published online: 10 OCT 2007
- Article first published online: 10 OCT 2007
- Accepted for publication May 2, 2007
- Parkinson’s disease;
- cognitive impairment;
- blood flow;
- Alzheimer’s disease
Objectives – The aim of the study was to visualize cortical function in Parkinson’s patients with various degrees of cognitive impairment.
Materials and methods – Thirty-seven patients with Parkinson’s disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT.
Results – Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10).
Conclusions – The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.