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Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson’s disease – a rCBF scintigraphy study


Anders Wallin, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Göteborg University, Mölndal SE-431 80, Sweden.
Tel.: +46 31 3431000
Fax: +46 31 7769055


Objectives –  The aim of the study was to visualize cortical function in Parkinson’s patients with various degrees of cognitive impairment.

Materials and methods –  Thirty-seven patients with Parkinson’s disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT.

Results –  Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10).

Conclusions –  The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.