Transcranial magnetic stimulation for differential diagnostics in patients with parkinsonism
Article first published online: 13 FEB 2008
Copyright © 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Acta Neurologica Scandinavica
Volume 118, Issue 3, pages 159–163, September 2008
How to Cite
Morita, Y., Osaki, Y. and Doi, Y. (2008), Transcranial magnetic stimulation for differential diagnostics in patients with parkinsonism. Acta Neurologica Scandinavica, 118: 159–163. doi: 10.1111/j.1600-0404.2007.00988.x
- Issue published online: 12 AUG 2008
- Article first published online: 13 FEB 2008
- Accepted for publication December 17, 2007
- Parkinson's disease;
- progressive supranuclear palsy;
- multiple system atrophy;
- transcranial magnetic stimulation
Objective – We investigated transcranial magnetic stimulation (TMS) parameters in patients with parkinsonism, particularly in the early stages of the disease.
Subjects and methods – We performed TMS in 48 patients with PD, progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We measured motor threshold (MT), latency (L), motor-evoked potential amplitude and central motor conduction time (CMCT) and cortical silent period (CSP). Furthermore, we selected and compared 27 patients with a disease duration of less than 3 years.
Results – CMCT, MT, L and CSP were different among the three groups. Post hoc analyses revealed that CMCT and CSP were the shortest in PD, and that MT was significantly lower in PD than in MSA. In patients whose disease duration was less than 3 years, CMCT and CSP were different among the three groups. Post hoc analyses showed significantly shorter CMCT in PD.
Conclusions – TMS can detect the pathophysiological difference among the groups in the early stages of the disease.