Pallidal deep brain stimulation in the treatment of Meige syndrome


Patric Blomstedt, Department of Neurosurgery, University Hospital of Northern Sweden, 901 85 Umeå, Sweden
Tel.: +46 90 785 0000
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Background –  Pallidal deep brain stimulation (DBS) of globus pallidus internus (Gpi) has emerged as an effective treatment for dystonia. The experience is however limited concerning focal dystonias and to date only a few cases of pallidal DBS in the treatment of Meige syndrome have been published.

Methods/results –  We here present a patient with Meige syndrome in whom unilateral pallidal DBS failed to improve the axial symptoms, but bilateral stimulation resulted in a major improvement. The Burke-Fahn-Marsden score (BFM) improved by 71.5% and the patient’s blepharospasm was abolished.

Conclusions –  The results suggest bilateral pallidal DBS may be an effective treatment for Meige syndrome.