Conflict of Interests: The authors declare no conflicts of interest.
Management of neuroborreliosis in European adult patients
Article first published online: 24 APR 2008
Copyright © 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Acta Neurologica Scandinavica
Special Issue: Selected articles from the Annual Meeting of the Norwegian Neurological Association,Oslo 26-30 November 2007
Volume 117, Issue Supplement s188, pages 22–28, May 2008
How to Cite
Ljøstad, U. and Henriksen, T.-H. (2008), Management of neuroborreliosis in European adult patients. Acta Neurologica Scandinavica, 117: 22–28. doi: 10.1111/j.1600-0404.2008.01027.x
- Issue published online: 24 APR 2008
- Article first published online: 24 APR 2008
- Accepted for publication
- Lyme neuroborreliosis;
- Borrelia burgdorferi
Objectives – To survey present knowledge and controversies in European neuroborreliosis.
Material and methods – The article is based on available literature, own experience, and a speech held by the authors together on the Norwegian annual neurological meeting.
Results – Diagnosis of neuroborreliosis is based on clinical neurological findings, laboratory support of borrelia infection, and indications of causality between neurological findings and borreliosis. In the absence of means to identify B. burgdorferi, antibody tests are used for laboratory diagnosis. Two to three weeks courses of IV penicillin or ceftriaxone are highly effective in neuroborreliosis. Oral doxycyclin is probably equally effective. Remaining symptoms five years after treatment for neuroborreliosis are reported in 25–50% of patients.
Conclusions – We suggest two levels of diagnostic accuracy; definite and possible neuroborreliosis. These case definitions are proposed to make the basis for treatment decisions. The prognosis of neuroborreliosis and pathophysiology of post-treatment conditions need further studies. Extensive treatments with antibiotics are not recommended.