These two authors contributed equally for the study.
Examination of the MSX1 gene in patients with Parkinson’s disease
Article first published online: 13 NOV 2009
Copyright © 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Acta Neurologica Scandinavica
Volume 120, Issue 6, pages 442–444, December 2009
How to Cite
Deng, H., Zhu, S. H., Le, W. D., Yang, H. R., Lv, H. W., Xu, H. B., Xie, W. J. and Jankovic, J. (2009), Examination of the MSX1 gene in patients with Parkinson’s disease. Acta Neurologica Scandinavica, 120: 442–444. doi: 10.1111/j.1600-0404.2009.01271.x
- Issue published online: 13 NOV 2009
- Article first published online: 13 NOV 2009
- Accepted for publication September 3, 2009
- Parkinson’s disease;
- muscle segment homeobox drosophila homolog of 1 gene;
- transcription factor;
- coding region
Background – Several genetic variants in transcription factor genes have been reported to be associated with Parkinson’s disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.
Aims of the study – To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.
Methods – We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.
Results – No mutation in the MSX1 gene was identified in our cohort.
Conclusions – Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.