SEARCH

SEARCH BY CITATION

Keywords:

  • Parkinson’s disease;
  • muscle segment homeobox drosophila homolog of 1 gene;
  • transcription factor;
  • mutation;
  • coding region

Background –  Several genetic variants in transcription factor genes have been reported to be associated with Parkinson’s disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.

Aims of the study –  To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.

Methods –  We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.

Results –  No mutation in the MSX1 gene was identified in our cohort.

Conclusions –  Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.