Cerebral vasomotor reactivity and dementia after ischemic stroke
Version of Record online: 19 JAN 2010
Copyright © 2010 The Authors. Journal compilation © 2010 Blackwell Munksgaard
Acta Neurologica Scandinavica
Volume 122, Issue 6, pages 383–388, December 2010
How to Cite
Gur, A. Y., Gücüyener, D., Korczyn, A. D., Üzüner, N., Gilutz, Y., Özdemir, G. and Bornstein, N. M. (2010), Cerebral vasomotor reactivity and dementia after ischemic stroke. Acta Neurologica Scandinavica, 122: 383–388. doi: 10.1111/j.1600-0404.2010.01323.x
- Issue online: 19 JAN 2010
- Version of Record online: 19 JAN 2010
- Accepted for publication December 17, 2009
- brain infarct;
- cerebrovascular reactivity;
- Doppler ultrasonography;
- ischemic stroke;
- post-stroke dementia
Gur AY, Gücüyener D, Korczyn AD, Üzüner N, Gilutz Y, Özdemir G, Bornstein NM. Cerebral vasomotor reactivity and dementia after ischemic stroke. Acta Neurol Scand: 2010: 122: 383–388. © 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.
Objectives – Cerebral hemodynamic features of patients with post-stroke dementia (PSD) are still obscure. We compared cerebral vasomotor reactivity (VMR) assessed in the acute phase of ischemic stroke (IS) in patients with and without PSD. VMR was also assessed and compared in demented and non-demented patients in the late phase of IS.
Materials and methods – VMR was assessed by transcranial Doppler and the Diamox test (1 g acetazolamide i.v.). PSD was confirmed by the National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et I’Enseignement en Neurosciences (NINDS-AIREN) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. VMR% values were compared to verify correlation with dementia.
Results – Thirty patients with acute IS (AIS) were studied and followed for 3–6 months. An additional group of 37 patients was studied in the late post-stroke period (PIS). VMR% values in the AIS groups with and without PSD were similar (25.3 ± 20.3% and 36.5 ± 22.4%, respectively, NS). The mean VMR% in the PIS groups with and without PSD were similar (32.3 ± 19.5% and 41.2 ± 24.8%, respectively, NS).
Conclusions – VMR cannot predict the development of dementia after AIS and cannot identify patients with dementia in the late phase of stroke.