Active and passive smoking and risk of Parkinson’s disease

  1. K. Tanaka1,
  2. Y. Miyake1,
  3. W. Fukushima2,
  4. S. Sasaki3,
  5. C. Kiyohara4,
  6. Y. Tsuboi5,
  7. T. Yamada5,
  8. T. Oeda6,
  9. T. Miki7,
  10. N. Kawamura8,
  11. N. Sakae8,
  12. H. Fukuyama9,
  13. Y. Hirota2,
  14. M. Nagai10,
  15. the Fukuoka Kinki Parkinson’s disease Study Group†

Article first published online: 17 FEB 2010

DOI: 10.1111/j.1600-0404.2010.01327.x

Issue

Acta Neurologica Scandinavica

Acta Neurologica Scandinavica

Volume 122, Issue 6, pages 377–382, December 2010

Additional Information

How to Cite

Tanaka, K., Miyake, Y., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. and the Fukuoka Kinki Parkinson’s disease Study Group (2010), Active and passive smoking and risk of Parkinson’s disease. Acta Neurologica Scandinavica, 122: 377–382. doi: 10.1111/j.1600-0404.2010.01327.x

Author Information

  1. 1

    Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka

  2. 2

    Department of Public Health, Osaka City University Graduate School of Medicine, Osaka

  3. 3

    Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo

  4. 4

    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka

  5. 5

    Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka

  6. 6

    Department of Neurology, Utano National Hospital, Kyoto

  7. 7

    Department of Geriatric Medicine, Osaka City University Graduate School of Medicine, Osaka

  8. 8

    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka

  9. 9

    Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto

  10. 10

    Department of Public Health, Saitama Medical University Faculty of Medicine, Saitama, Japan

  1. †

    Other members of the Study Group are listed in the Appendix.

*Yoshihiro Miyake, MD, PhD, Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan Tel.: +81 92 801 1011 (ext. 3311) Fax: +81 92 863 8892 e-mail: miyake-y@fukuoka-u.ac.jp

Publication History

  1. Issue published online: 17 FEB 2010
  2. Article first published online: 17 FEB 2010
  3. Accepted for publication December 17, 2009

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Keywords:

  • case–control studies;
  • Japan;
  • Parkinson’s disease;
  • passive smoking;
  • smoking

Tanaka K, Miyake Y, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, the Fukuoka Kinki Parkinson’s disease Study Group. Active and passive smoking and risk of Parkinson’s disease. Acta Neurol Scand: 2010: 122: 377–382. © 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.

Objective –  To assess the association between active and passive smoking and the risk of Parkinson’s disease (PD), a case–control study with 249 PD patients and 369 controls was carried out in Japan.

Methods –  Information on smoking was obtained through a self-administered questionnaire. Adjustment was made for age, sex, region of residence, educational level, and occupational exposure.

Results –  Ever having smoked cigarettes was associated with a reduced risk of PD [adjusted odds ratio = 0.38; 95% confidence interval (CI): 0.24–0.59]. Risk for former smokers was intermediate between the high risk for never smokers and the low risk for current smokers. Adjusted odds ratios for former and current smokers were 0.51 (95% CI: 0.32–0.82) and 0.12 (95% CI: 0.05–0.26), respectively. There was an inverse dose-response gradient with pack-years smoked. No significant association was detected for passive smoking exposure.

Conclusion –  Our results appear to confirm data from previous epidemiological studies.

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