Alfstad KÅ, Lossius MI, Røste GK, Mowinckel P, Scheie D, Borota OC, Larsson PG, Nakken KO. Acute postoperative seizures after epilepsy surgery – a long-term outcome predictor?
Acta Neurol Scand: 2011: 123: 48–53.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.
Objectives – The prognostic value of acute postoperative seizures (APS) after epilepsy surgery is much debated. This study evaluated APS, defined as seizures in the first week post-surgery, as a predictor of long-term seizure outcome, and investigated the utility of other potential outcome predictors.
Materials and methods – Medical records of 48 patients with temporal and extra-temporal epilepsy surgery were studied. Forty patients had lesional surgery. All had at least 2 year postoperative follow-up.
Results – At 2 year follow-up, 25 patients (53%) were seizure free. Univariate analysis showed that APS (P = 0.048), using ≥six AEDs prior to surgery (P = 0.03), pathological postoperative EEG (P = 0.043) and female gender (P = 0.012) were associated with seizure recurrence.
Conclusions – Univariate analysis indicate that APS, a high number of AEDs used prior to surgery, and pathological postoperative EEG are possible predictors of seizure recurrence after epilepsy surgery. Only gender retained significance in the multivariate analysis.