Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes
Article first published online: 18 JUL 2010
© 2010 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 123, Issue 2, pages 105–110, February 2011
How to Cite
They-They, T. P., Nadifi, S., Rafai, M. A., Battas, O. and Slassi, I. (2011), Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes. Acta Neurologica Scandinavica, 123: 105–110. doi: 10.1111/j.1600-0404.2010.01348.x
- Issue published online: 4 JAN 2011
- Article first published online: 18 JUL 2010
- Accepted for publication February 4, 2010
- ischemic stroke;
- MTHFR polymorphism;
- Moroccan population
They-They TP, Nadifi S, Rafai MA, Battas O, Slassi I. Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes. Acta Neurol Scand: 2011: 123: 105–110. © 2010 John Wiley & Sons A/S.
Background – The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial.
Method – This first case–control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion.
Results – We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59–2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke (n = 42); odds ratio, 2.1; 95% CI: 1.17–3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI: 1.86–23.1, P = 0.003, for TT genotype variant compared with CC wild genotype.
Conclusion – We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco.