The role of apolipoprotein E polymorphisms in levodopa-induced dyskinesia

Authors

  • I. Molchadski,

    1. Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Tel-Aviv, Israel
    2. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
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  • A. D. Korczyn,

    1. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
    2. Sieratzki Chair of Neurology, Tel Aviv University, Tel-Aviv, Israel
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  • O. S. Cohen,

    1. Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Tel-Aviv, Israel
    2. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
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  • A. Katzav,

    1. Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Tel-Aviv, Israel
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  • Z. Nitzan,

    1. Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Tel-Aviv, Israel
    2. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
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  • J. Chapman,

    1. Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Tel-Aviv, Israel
    2. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
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  • S. Hassin-Baer

    1. Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Tel-Aviv, Israel
    2. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
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Dr Sharon Hassin-Baer, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Tel-Aviv 52621, Israel
Tel.: +972 35305791
Fax: +972 35305323
e-mail: shassin@post.tau.ac.il

Abstract

Molchadski I, Korczyn AD, Cohen OS, Katzav A, Nitzan Z, Chapman J, Hassin-Baer S. The role of apolipoprotein E polymorphisms in levodopa-induced dyskinesia.
Acta Neurol Scand: 2011: 123: 117–121.
© 2010 John Wiley & Sons A/S.

Objectives –  To determine the relationship between apolipoprotein E (APOE) polymorphisms to the time to appearance of levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease.

Methods –  The APOE genotype of 155 consecutive patients treated with levodopa was determined and its effect on the time of onset of LID was examined using Cox regression model, controlling for gender, age of disease onset, time to initiation of levodopa treatment and history of smoking.

Results –  Two patients were homozygous for the APOE ε2 allele, 7 had ε2/ε3, 1 had ε2/ε4, 130 had ε3/ε3, 12 had ε3/ε4 and 3 had ε4/ε4; LID appeared in 57.4% of the patients, appearing 4.1 ± 3.5 years after the initiation of levodopa treatment. The survival curve for LID was not affected by the APOE genotype (P = 0.34).

Conclusion –  APOE polymorphisms were found not to be associated with either the occurrence or the time to development of LID.

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