Detection of the membrane attack complex as a diagnostic tool in dermatomyositis
Article first published online: 17 MAY 2010
© 2010 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 123, Issue 2, pages 122–129, February 2011
How to Cite
Jain, A., Sharma, M. C., Sarkar, C., Bhatia, R., Singh, S., Gulati, S. and Handa, R. (2011), Detection of the membrane attack complex as a diagnostic tool in dermatomyositis. Acta Neurologica Scandinavica, 123: 122–129. doi: 10.1111/j.1600-0404.2010.01353.x
- Issue published online: 4 JAN 2011
- Article first published online: 17 MAY 2010
- Accepted for publication February 16, 2010
- idiopathic inflammatory myopathy;
- inclusion body myositis;
- membrane attack complex;
Jain A, Sharma MC, Sarkar C, Bhatia R, Singh S, Gulati S, Handa R. Detection of the membrane attack complex as a diagnostic tool in dermatomyositis. Acta Neurol Scand: 2011: 123: 122–129. © 2010 John Wiley & Sons A/S.
Background – Currently there is no reliable diagnostic marker to distinguish between the subgroups of idiopathic inflammatory myopathies (IIMs), i.e. dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). Membrane attack complex (MAC) has been shown to be involved in the pathogenesis of dermatomyositis but its role as a diagnostic marker has not been evaluated.
Aim – To assess the diagnostic utility of MAC deposition in distinguishing dermatomyositis from other neuromuscular disorders.
Material and methods – Immunohistochemical detection of MAC deposition on endomysial microvessels was carried out on 127 muscle biopsies comprising of 21 cases of dermatomyositis, 42 other IIMs and 64 non-IIM neuromuscular diseases.
Results – MAC deposition showed a high sensitivity (80.9%) and specificity (85%) to differentiate DM from other IIMs. Its specificity was higher (98.4%) in discriminating DM from non-IIM muscular diseases and IIM from non-IIMs.
Conclusion – MAC deposition can serve as a reliable marker to distinguish DM from other IIMs (i.e. PM and IBM) as well as from non-IIM diseases. It can also serve as a useful adjunct in diagnosis of IIMs when there is diagnostic dilemma with their morphologic similarities. These results provide further credence to the long-standing view that MAC-mediated capillary destruction is involved in the immunopathogenesis of DM.