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The role of APOE alleles in incident Parkinson’s disease. The Norwegian ParkWest Study

Authors

  • H. Vefring,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. Department of Medical Biochemistry, Stavanger University Hospital, Stavanger, Norway
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  • K. Haugarvoll,

    1. Department of Neurology, Haukeland University Hospital, Bergen, Norway
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  • O.-B. Tysnes,

    1. Department of Neurology, Haukeland University Hospital, Bergen, Norway
    2. School of Medicine, University of Bergen, Norway
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  • J. P. Larsen,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. School of Medicine, University of Bergen, Norway
    3. Department of Neurology, Stavanger University Hospital, Stavanger, Norway
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  • M. W. Kurz,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. Department of Neurology, Stavanger University Hospital, Stavanger, Norway
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  • for the Norwegian ParkWest Study group

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    • Members of the Norwegian ParkWest Study group are listed in the Appendix.


Martin Kurz, Department of Neurology, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway
Tel.: 0047-51518426
Fax: 0047-51519916
e-mail: kuma@sus.no

Abstract

Vefring H, Haugarvoll K, Tysnes O-B, Larsen JP, Kurz MW, for the Norwegian ParkWest Study group. The role of APOE alleles in incident Parkinson’s disease. The Norwegian ParkWest Study.
Acta Neurol Scand: 2010: 122: 438–441.
© 2010 John Wiley & Sons A/S.

Objectives – Apolipoprotein E (APOE) gene alleles have been associated with various neurodegenerative disorders. However, there have been conflicting reports on associations between APOE alleles and Parkinson’s disease (PD) and age at onset in PD. There exist no data on APOE alleles in an unselected cohort of patients with incident PD.

Patients and methods –  To determine the role of APOE alleles in PD and age of onset in PD at time of diagnosis, 203 patients with incident PD and 187 healthy control subjects from Western and Southern Norway were investigated according to their APOE allele status.

Results –  No association was observed between any APOE alleles and susceptibility to PD or age at onset in PD.

Conclusion –  In our cohort of unselected, incident PD patients APOE alleles do not seem to play a role for development of PD. Prospective, long-term follow-up may still reveal associations between APOE alleles and clinical and neuropsychological progression in PD.

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