These authors contributed equally to this work.
LINGO1 variants in essential tremor and Parkinson’s disease
Article first published online: 7 APR 2011
© 2011 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 125, Issue 1, pages 1–7, January 2012
How to Cite
Deng, H., Gu, S. and Jankovic, J. (2012), LINGO1 variants in essential tremor and Parkinson’s disease. Acta Neurologica Scandinavica, 125: 1–7. doi: 10.1111/j.1600-0404.2011.01516.x
- Issue published online: 21 DEC 2011
- Article first published online: 7 APR 2011
- Accepted for publication March 2, 2011
- disease risk;
- essential tremor;
- Parkinson’s disease;
Deng H, Gu S, Jankovic J. LINGO1 variants in essential tremor and Parkinson’s disease. Acta Neurol Scand: 2012: 125: 1–7 © 2011 John Wiley & Sons A/S.
The leucine-rich repeat and Ig domain containing 1 gene (LINGO1), recently considered to be conferred increased risk of essential tremor (ET), has been also implicated in Parkinson disease (PD). As the two common movement disorders have overlapping clinical and pathological features, it has been postulated that the LINGO1 gene may play a role in the pathogenesis of the two diseases. Here, we review published reports of the LINGO1 variants in ET and PD in an attempt to better understand the molecular and pathogenic relationship of LINGO1 to the two disorders.