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LINGO1 variants in essential tremor and Parkinson’s disease

Authors

  • H. Deng,

    1. Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, HN, China
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    • These authors contributed equally to this work.

  • S. Gu,

    1. Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, HN, China
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    • These authors contributed equally to this work.

  • J. Jankovic

    1. Department of Neurology, Baylor College of Medicine, Houston, TX, USA
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H. Deng, Center for Experimental Medicine and Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, HN 410013, China
Tel.: 011 86 731 8618372
Fax: 011 86 731 8618339
e-mail: hdeng008@yahoo.com

Abstract

Deng H, Gu S, Jankovic J. LINGO1 variants in essential tremor and Parkinson’s disease.
Acta Neurol Scand: 2012: 125: 1–7
© 2011 John Wiley & Sons A/S.

The leucine-rich repeat and Ig domain containing 1 gene (LINGO1), recently considered to be conferred increased risk of essential tremor (ET), has been also implicated in Parkinson disease (PD). As the two common movement disorders have overlapping clinical and pathological features, it has been postulated that the LINGO1 gene may play a role in the pathogenesis of the two diseases. Here, we review published reports of the LINGO1 variants in ET and PD in an attempt to better understand the molecular and pathogenic relationship of LINGO1 to the two disorders.

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