Present address: Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Isolated seizures in rats do not cause neuronal injury
Article first published online: 26 MAY 2011
Published 2011. This article is a US Government work and is in the public domain in the USA
Acta Neurologica Scandinavica
Volume 125, Issue 1, pages 30–37, January 2012
How to Cite
Acosta, M. T., Munashinge, J., Zhang, L., Guerron, D. A., Vortmeyer, A. and Theodore, W. H. (2012), Isolated seizures in rats do not cause neuronal injury. Acta Neurologica Scandinavica, 125: 30–37. doi: 10.1111/j.1600-0404.2011.01521.x
- Issue published online: 21 DEC 2011
- Article first published online: 26 MAY 2011
- Accepted for publication March 29, 2011
Acosta MT, Munashinge J, Zhang L, Guerron DA, Vortmeyer A, Theodore WH. Isolated seizures in rats do not cause neuronal injury. Acta Neurol Scand: 2012: 125: 30–37. Published 2011. This article is a US Government work and is in the public domain in the USA.
Background – Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain.
Methods – We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazole-4-yl)propanoic acid (ATPA), and α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate in rats. A group of animals received normal saline. After seizure induction, animals were followed for 12 weeks.
Results – ATPA and KA led to small but significant increases in ADC. There were no changes in T2 signal intensity or hippocampal volume. Blinded pathological examination showed no differences between animals receiving saline or glutamatergic agents.
Conclusion – Our study suggests that isolated seizures cause minimal neuronal injury in rats.