Intrathecal levels of vitamin D and IgG in multiple sclerosis
Article first published online: 23 JUL 2011
© 2011 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 125, Issue 6, pages e28–e31, June 2012
How to Cite
Holmøy, T., Lossius, A., Gundersen, T. E., Moen, S. M., Castellazzi, M., Fainardi, E. and Casetta, I. (2012), Intrathecal levels of vitamin D and IgG in multiple sclerosis. Acta Neurologica Scandinavica, 125: e28–e31. doi: 10.1111/j.1600-0404.2011.01577.x
- Issue published online: 20 APR 2012
- Article first published online: 23 JUL 2011
- Accepted for publication June 27, 2011
- multiple sclerosis;
- vitamin D;
- cerebrospinal fluid;
- immunoglobulin G;
Holmøy T, Lossius A, Gundersen TE, Moen SM, Castellazzi M, Fainardi E, Casetta I. Intrathecal levels of vitamin D and IgG in multiple sclerosis. Acta Neurol Scand: 2012: 125: e28–e31. © 2011 John Wiley & Sons A/S.
Background – Intrathecal synthesis of IgG is a hallmark of multiple sclerosis (MS). Vitamin D may modulate B-cell function and dampen the synthesis of IgG.
Objective – To investigate the relation between vitamin D levels in cerebrospinal fluid and serum and intrathecal synthesis of IgG.
Methods – 25-hydroxyvitamin D (25(OH)D) and IgG were assessed in cerebrospinal fluid and serum in 40 patients with MS.
Results – There was no significant correlation between the IgG index and 25(OH)D levels in cerebrospinal fluid or serum. The levels of 25(OH)D in cerebrospinal fluid and serum did not differ between patients with and without intrathecal synthesis of IgG. There was a non-significant trend towards a positive correlation between the concentrations of 25(OH)D and IgG in the cerebrospinal fluid, but not in serum.
Conclusion – Physiological variation in vitamin D does not exert a major impact on intrathecal synthesis of IgG in MS.