Lambert–Eaton myasthenic syndrome following H1N1-influenza vaccination – a case report


H. Ansakorpi, Department of Neurology, Oulu University Hospital, BOX 25, FI-90029 OYS, Finland

Tel.: +358 8 3154065

Fax: +358 8 3154544




The outbreak of influenza A (H1N1) pandemic during the year 2009 led to the development of several vaccinations against H1N1 virus. In Finland, 2.6 million citizens were vaccinated during pandemic 2009 – 2010 with adjuvanted influenza vaccine, Pandemrix®.

Clinical Presentation

In this case report, we describe a patient with non-paraneoplastic Lambert–Eaton myasthenic syndrome following Pandemrix® vaccination.


Development of various autoimmune diseases in genetically predisposed subjects following exposure to certain environmental factors, including vaccinations, is a well-known entity. Clinicians should be aware of the possibility of the induction of autoimmune diseases following vaccinations and actively ask the relevant clinical history in a newly diagnosed patient with an autoimmune disorder.