Risk factor burden predicts long-term mortality in young patients with arterial cerebral infarction
Article first published online: 23 MAY 2012
© 2012 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 127, Issue 2, pages 92–96, February 2013
How to Cite
Naess H, Waje-Andreassen U, Nyland H. Risk factor burden predicts long-term mortality in young patients with arterial cerebral infarction. Acta Neurol Scand: 2013: 127: 92–96. © 2012 John Wiley & Sons A/S.
- Issue published online: 22 JAN 2013
- Article first published online: 23 MAY 2012
- Manuscript Accepted: 17 APR 2012
- cerebrovascular diseases;
- risk factors;
The aim was to investigate risk factors separately and in sum in relation to long-term mortality after arterial cerebral infarction in young adults.
Materials and methods
Mortality in relation to the number of risk factors (smoking, hypertension, hypercholesterolemia, diabetes mellitus, myocardial infarction, angina pectoris, and intermittent claudication known at the time of the index stroke) and etiology was studied in a population of young adults with first-ever arterial ischemic stroke at an age < 50 years. Cox regression analyses were performed.
After a mean follow-up time of 18 years (the longest follow-up study after cerebral infarction in young adults), 12.5% with no risk factor had died while the corresponding frequencies in patients with 1–3 or more risk factors were 18.5%, 25.4%, and 53.1%, respectively (P < 0.001). The number of risk factors was associated with mortality on Cox regression analysis [hazard ratio (HR) = 1.6, P = 0.001]. A separate Cox regression analysis showed mortality to be associated with diabetes mellitus (HR = 3.0, P = 0.001), myocardial infarction (HR = 3.1, P = 0.001), and alcoholism (HR = 6.3, P < 0.001).
Increasing number of traditional risk factors is associated with long-term mortality in young adults with cerebral infarction indicating aggressive long-term secondary preventive treatment in selected patients.