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Keywords:

  • alcohol;
  • cohort study;
  • epidemiology;
  • risk factors;
  • stroke

Objectives

The aim of this study was to examine the association between hangover and the risk of stroke.

Material and methods

A population-based sample of men with an average follow-up of 15.7 years. 2466 men with no history of stroke at baseline participated. Two hundred and six strokes occurred, of which 167 were ischemic strokes.

Results

The age-adjusted, relative risk (RR) for any stroke among men with ≥1 hangover per year was 2.33-fold (95% confidence interval (CI), 1.19–4.56; P = 0.013) relative to men without hangover, and 2.99-fold (95% CI, 1.52–5.86; P = 0.001) for ischemic stroke, respectively. After adjustment for age, smoking, high density lipoprotein (HDL)-cholesterol, LDL-cholesterol, BMI, SBP, myocardial ischemia during exercise, symptomatic coronary heart disease (CHD) and CHD in family, C-reactive protein, diabetes, and total alcohol consumption, the RR for any stroke was 1.94-fold (95% CI, 0.95–3.96; P = 0.070) and 2.58-fold (95% CI, 1.24–5.36; P = 0.011) for ischemic stroke among men with hangovers. Additional adjustment of atrial fibrillation and cardiac failure and risk was 2.45-fold (95% CI, 1.18–5.12; P = 0.017) for ischemic strokes.

Conclusion

This study shows that at least one hangover a year is related to an increased risk of ischemic stroke in men.