Use of analgesic drugs and risk of ovarian cancer: results from a Danish case–control study

Authors


  • Conflict of interest
    The authors have stated explicitly that there are no conflicts of interest in connection with this article.

  • Please cite this article as: Ammundsen HB, Faber MT, Jensen A, Høgdall E, Blaakær J, Høgdall C, et al. Use of analgesic drugs and risk of ovarian cancer: results from a Danish case–control study. Acta Obstet Gynecol Scand 2012; 91:1094–1102.

Susanne Krüger Kjær, Danish Cancer Society Research Center, Virus, Lifestyle and Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. E-mail: susanne@cancer.dk

Abstract

Objective. The role of analgesic drug use in development of ovarian cancer is not fully understood. We examined the association between analgesic use and risk of ovarian cancer. In addition, we examined whether the association differed according to histological types. Design. Population-based case–control study. Setting. Denmark in the period 1995–1999. Population. We included 756 women with epithelial ovarian cancer and 1564 randomly selected control women aged 35–79 years. Methods. Information on analgesic drug use was collected from personal interviews. Analgesic drugs were divided into the following categories: any analgesics; aspirin; non-aspirin non-steroidal anti-inflammatory drugs; paracetamol; and other analgesic drugs. The association between analgesic drug use and ovarian cancer risk was analysed using multiple logistic regression models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Main outcome measures. Epithelial ovarian cancer. Results. Women with a regular use of any analgesics (OR = 0.79; 95% CI 0.62 − 1.01) or aspirin (OR = 0.68; 95% CI 0.46 − 1.02) had a decreased risk of ovarian cancer, although not statistically significant. Regular use of non-aspirin non-steroidal anti-inflammatory drugs, paracetamol or other analgesics did not decrease ovarian cancer risk. Use of any analgesics (OR = 0.72; 95% CI 0.53–0.98) or aspirin (OR = 0.60; 95% CI 0.36–1.00) resulted in a statistically significant decreased risk of serous ovarian cancer but not mucinous or other ovarian tumors. Conclusion. In accordance with most previous studies, our results indicate a possible inverse association between analgesic use, particularly aspirin, and ovarian cancer risk.

Ancillary