Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article.
SHORT RESEARCH REPORT
Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function
Article first published online: 1 NOV 2012
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology
Acta Obstetricia et Gynecologica Scandinavica
Volume 91, Issue 12, pages 1465–1468, December 2012
How to Cite
GZIRI, M. M., DEBIÈVE, F., DE CATTE, L., MERTENS, L., BARREA, C., VAN CALSTEREN, K., HAN, S. N., HEYNS, L. and AMANT, F. (2012), Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function. Acta Obstetricia et Gynecologica Scandinavica, 91: 1465–1468. doi: 10.1111/j.1600-0412.2012.01524.x
Please cite this article as: Gziri MM, Debiève F, De Catte L, Mertens L, Barrea C, Van Calsteren K, Han SN, Heyns L, Amant F. Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function. Acta Obstet Gynecol Scand. 2012;91: DOI: 10.1111/j.1600-0412.2012.01524.x.
- Issue published online: 5 DEC 2012
- Article first published online: 1 NOV 2012
- Accepted manuscript online: 10 AUG 2012 07:25AM EST
- Received: 15 February 2012 Accepted: 1 August 2012
Chemotherapy and especially anthracyclines are associated to cardiotoxicity. To assess this potential risk during pregnancy a clinical case–control trial was conducted. Maternal cardiac function, fetal Doppler and fetal cardiac function were evaluated before and after chemotherapy. Maternal cardiac function was assessed by echocardiography before and after the third cycle of anthracyclines and compared with a control group of 10 non-pregnant women matched for age, type of cancer and anthracycline treatment. Ten fetuses exposed to chemotherapy were compared with 10 control fetuses matched for gestational age and gender. Biometry, amniotic fluid index, fetal Doppler and cardiac function were assessed before and after each cycle of chemotherapy. In all, 108 fetal ultrasounds scans were performed before and after 36 cycles of chemotherapy. Anthracycline exposure did not result in acute maternal and fetal cardiac dysfunction in this small cohort study.