Transpupillary thermotherapy for the treatment of subfoveal choroidal neovascularization associated with age-related macular degeneration
Article first published online: 28 SEP 2004
Acta Ophthalmologica Scandinavica
Volume 82, Issue 5, pages 585–590, October 2004
How to Cite
Tranos, P., Singh, M., Peter, N. M., Dhir, L., Kon, C. and Rassam, S. (2004), Transpupillary thermotherapy for the treatment of subfoveal choroidal neovascularization associated with age-related macular degeneration. Acta Ophthalmologica Scandinavica, 82: 585–590. doi: 10.1111/j.1600-0420.2004.00327.x
- Issue published online: 28 SEP 2004
- Article first published online: 28 SEP 2004
- Received on November 13th, 2003. Accepted on May 19th, 2004.
- subfoveal choroidal neovascularization;
- transpupillary thermotherapy;
- age-related macular degeneration
Objective: To evaluate the efficacy of transpupillary thermotherapy (TTT) for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
Design: Prospective, non-randomized, non-masked, case-selected series.
Methods: All patients with subfoveal CNV due to AMD and initial visual acuity (VA) between 6/9 and 6/60 were offered the opportunity to undergo TTT. Recruited subjects were treated using a diode laser (810 nm) with a beam size of 1.2–3.0 mm and power settings of 460–1200 mW. Treatment was applied for 60 seconds in a subthreshold manner.
Main outcome measures: Differences in VA and changes in the angiographic appearance of CNV.
Results: Thirty-one occult/predominantly occult and five classic/predominantly classic membranes were treated with TTT and were followed-up for a mean of 6.0 ± 1.2 months. Following an average of 1.5 ± 0.7 (range 1–4) laser sessions, VA remained stable ( − 1 to + 1 Snellen line) in 24 (66.7%) eyes, improved by > 1 line in two (5.6%) eyes and decreased significantly (≥ 2 Snellen lines) in 10 (27.8%) eyes. Angiographically confirmed closure of CNV was detected in 22 (61.1%) patients. Membranes persisted in 11 (30.6%) eyes and recurred in three (8.3%) eyes. There was no association between reduction, elimination or persistence of angiographic leakage of CNV and change in VA after treatment (p = 0.347).
Conclusions: Transpupillary thermotherapy may be effective at preserving vision and reducing CNV leakage in a number of patients with exudative AMD. Further studies are required to compare TTT with the natural course of subfoveal CNV and alternative treatment options.