Intravitreal triamcinolone for macular oedema: efficacy in relation to aetiology

Authors

  • Torben Lykke Sørensen,

    Corresponding author
    1. Department of Ophthalmology, University of Copenhagen, Herlev Hospital, Herlev, Denmark
      Torben Lykke Sørensen MD
      Department of Ophthalmology
      Herlev Hospital
      Herlev Ringvej 75
      2730 Herlev
      Denmark
      Tel: + 45 44 88 46 66
      Fax: + 45 44 94 10 41
      Email: torbenls@dadlnet.dk
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  • Per Haamann,

    1. Department of Ophthalmology, University of Copenhagen, Herlev Hospital, Herlev, Denmark
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  • Jørgen Villumsen,

    1. Department of Ophthalmology, University of Copenhagen, Herlev Hospital, Herlev, Denmark
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  • Michael Larsen

    1. Department of Ophthalmology, University of Copenhagen, Herlev Hospital, Herlev, Denmark
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Torben Lykke Sørensen MD
Department of Ophthalmology
Herlev Hospital
Herlev Ringvej 75
2730 Herlev
Denmark
Tel: + 45 44 88 46 66
Fax: + 45 44 94 10 41
Email: torbenls@dadlnet.dk

Abstract.

Purpose: To evaluate the efficacy and safety of intravitreal triamcinolone in patients with macular oedema of varying aetiology.

Methods: Two milligrams of intravitreal triamcinolone acetonide was injected into 34 eyes with persistent macular oedema (17 eyes with macula oedema secondary to posterior uveitis, 13 eyes with diabetic retinopathy, and four with pseudophakic macular oedema). Best corrected visual acuity was determined and transfoveal optical coherence tomography performed after 1 week, 1 month, 3 months and 6 months.

Results: Treatment improved visual acuity and subjective visual quality, and reduced foveal thickness in eyes with posterior uveitis and eyes with macular oedema secondary to diabetic retinopathy. Eyes treated for pseudophakic cystoid macular oedema demonstrated no improvement. A total of 32% of patients experienced a significant post-injection increase in intraocular pressure. Endophthalmitis, rhegmatogenous retinal detachment and cataract were absent.

Conclusion: Intravitreal triamcinolone appears to induce marked a improvement in macular oedema secondary to non-infectious uveitis and diabetic retinopathy.

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