A case of Chandler's syndrome revealed by ultrastructural studies of the trabecular meshwork
Article first published online: 16 FEB 2005
Acta Ophthalmologica Scandinavica
Volume 83, Issue 1, pages 113–114, February 2005
How to Cite
Awai, M., Futa, R., Hamanaka, T., Hirata, A., Koga, T., Kimura, A., Miyagawa, T. and Tanihara, H. (2005), A case of Chandler's syndrome revealed by ultrastructural studies of the trabecular meshwork. Acta Ophthalmologica Scandinavica, 83: 113–114. doi: 10.1111/j.1600-0420.2005.00389.x
- Issue published online: 16 FEB 2005
- Article first published online: 16 FEB 2005
- Received on February 16th, 2004. Accepted on September 22nd, 2004.
- basement membrane-like tissue;
- inflammatory cell;
Purpose: To investigate ultrastructural changes in the aqueous outflow route and discuss the mechanisms associated with intraocular pressure (IOP) elevation in a patient with presumably early stage Chandler's syndrome.
Methods: A 47-year-old man underwent trabeculectomy because of elevated IOP. A specimen obtained during surgery was studied by transmission electron microscopy.
Results: Electron microscopy showed the presence of a monolayer composed of corneal endothelium-like cells and thick basement membrane-like material. Neovascularization was also observed in the corneoscleral trabeculum.
Conclusions: Our results indicate that several mechanisms, including the formation of basement membrane-like tissue, infiltration of inflammatory cells and neovascularization, might contribute to the elevation of IOP in Chandler's syndrome. These may occur even when there is no history of conspicuous inflammatory reaction in the anterior ocular segments.