Group IIA phospholipase A2 concentration of tears in patients with ocular rosacea
Article first published online: 19 JUL 2005
Acta Ophthalmologica Scandinavica
Volume 83, Issue 4, pages 483–486, August 2005
How to Cite
Kari, O., Aho, V. V., Peltonen, S., Saari, J. M., Kari, M., Määttä, M., Collan, Y. and Saari, K. M. (2005), Group IIA phospholipase A2 concentration of tears in patients with ocular rosacea. Acta Ophthalmologica Scandinavica, 83: 483–486. doi: 10.1111/j.1600-0420.2005.00495.x
- Issue published online: 19 JUL 2005
- Article first published online: 19 JUL 2005
- Received on April 28th, 2004. Accepted on April 2nd, 2005.
- dry eye;
- meibomian glands;
- phospholipase A2;
Purpose: To determine the concentration of group IIA phospholipase A2 (GIIAPLA2) in tears of patients with ocular rosacea, and to compare it with GIIAPLA2 concentration in tears of age-matched healthy controls.
Methods: The GIIAPLA2 concentration in tears was measured with a time-resolved fluoroimmunoassay in 21 patients with ocular rosacea (mean age 55.6±9.2 years) and in 21 normal subjects (mean age 53.4±8.2 years). Conjunctival brush cytology was carried out and eosinophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epithelial cells, metaplastic changes and goblet cells were calculated separately.
Results: The GIIAPLA2 concentration in tears was statistically significantly lower in patients with ocular rosacea (31.0±18.4 µg/ml, p=0.0099) and, more specifically, in patients who had dry eye (25.8±15.1 µg/ml, p=0.0034), compared to that in normal controls. There was no correlation between the GIIAPLA2 content of tears and the conjunctival cells collected by the brush cytology.
Conclusion: The tears of patients with dry eye symptoms due to ocular rosacea have decreased GIIAPLA2 content. The pathogenic importance of this finding is discussed.