Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study
Article first published online: 7 APR 2006
Acta Ophthalmologica Scandinavica
Volume 84, Issue 3, pages 406–410, June 2006
How to Cite
Leonardi, A., Busca, F., Motterle, L., Cavarzeran, F., Fregona, I. A., Plebani, M. and Secchi, A. G. (2006), Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study. Acta Ophthalmologica Scandinavica, 84: 406–410. doi: 10.1111/j.1600-0420.2005.00622.x
- Issue published online: 16 MAY 2006
- Article first published online: 7 APR 2006
- Received on June 10th, 2005. Accepted on October 13th, 2005.
- ocular allergy;
- vernal keratoconjunctivitis;
- allergy diagnostic tests
Purpose: To evaluate the specific allergic sensitization and epidemiological characteristics of vernal keratoconjunctivitis (VKC).
Methods: This retrospective non-comparative case series included 406 VKC patients. Data included patient and family histories, and results of allergic tests. Annual incidence and prevalence rates were calculated for a cohort of 128 VKC patients from the greater Padua area.
Results: The great majority of VKC patients were male (76%), with a male : female ratio of 3.3 : 1. A skin prick test, specific serum IgE or conjunctival challenge was positive in 43%, 56% and 58% of patients, respectively. In the cohort of patients from the Padua area, the prevalence of the disease was 7.8/100 000, with a higher rate in young males (57/100 000) compared with young females (22/100 000), and lower rates in people over 16 years of age (3.8/100 000 in males, 1/100 000 in females). The incidence of VKC was 1/100 000, with a higher rate in males under 16 years of age (10/100 000) compared with females (4.2/100 000). In people over 16 years of age, the incidence of the disease was 0.06/100 000, with no difference between males and females.
Conclusion: An IgE-mediated sensitization was found in only half of the VKC patients. Vernal keratoconjunctivitis is not a rare event in the paediatric population but is an extremely rare new disease in adults.