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Retinal mean transit time in patients with primary open-angle glaucoma and normal-tension glaucoma

  1. Gunilla Bjärnhall1,
  2. Lidija Tomic1,
  3. Hiromu K. Mishima2,
  4. Hidetoshi Tsukamoto2,
  5. Albert Alm1

Article first published online: 17 NOV 2006

DOI: 10.1111/j.1600-0420.2006.00780.x

Issue

Acta Ophthalmologica Scandinavica

Acta Ophthalmologica Scandinavica

Volume 85, Issue 1, pages 67–72, February 2007

Additional Information

How to Cite

Bjärnhall, G., Tomic, L., Mishima, H. K., Tsukamoto, H. and Alm, A. (2007), Retinal mean transit time in patients with primary open-angle glaucoma and normal-tension glaucoma. Acta Ophthalmologica Scandinavica, 85: 67–72. doi: 10.1111/j.1600-0420.2006.00780.x

Author Information

  1. 1

    Department of Neuroscience, Ophthalmology, Uppsala University, Uppsala, Sweden

  2. 2

    Department of Ophthalmology and Visual Science, Division of Frontier Medical Science, Biomedical Research, Graduate School of Biomedical Sciences Hiroshima University, Hiroshima, Japan

*Albert Alm MD Department of Neuroscience, Ophthalmology University Hospital S-701 85 Uppsala Sweden Tel: + 46 18 611 51 36 Fax: + 46 18 50 48 57 Email: albert.alm@akademiska.se

Publication History

  1. Issue published online: 17 NOV 2006
  2. Article first published online: 17 NOV 2006
  3. Received on September 22nd, 2005. Accepted on June 29th, 2006.

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Keywords:

  • normal-tension glaucoma;
  • primary open-angle glaucoma;
  • retinal blood flow;
  • mean transit time;
  • visual field defects;
  • mean deviation

Abstract.

Purpose:  To compare the mean transit time (MTT) of retinal circulation in eyes with primary open-angle glaucoma (POAG) and eyes with normal-tension glaucoma (NTG) and examine the possible relationship between MTT and visual field damage, expressed as mean deviation (MD).

Methods:  Video fluorescein angiography was performed in 40 patients with POAG or NTG. Dye curves for fluorescein passing through the retinal arteries and veins were used to calculate MTT in each patient with a computer-assisted technique based on an impulse-response analysis (MTTir).

Results:  We were able to analyse MTTir in all 40 angiograms. Mean (SD) MTTir was 5.0 (1.5) seconds in eyes with POAG and 4.7 (1.4) seconds in eyes with NTG. The difference was not statistically significant. There was a weak but significant correlation between the MD and MTTir (MTTir = 4.12–0.08*MD; r = −0.49, p = 0.0013).

Conslusions:  The results demonstrate that loss of neuronal tissue in glaucoma is combined with an effect on the retinal circulation and that the effect is similar in eyes with NTG and eyes with POAG.

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