Pimozide combined with behavior therapy in the short-term treatment of anorexia nervosa

A DOUBLE-BLIND PLACEBO-CONTROLLED CROSS-OVER STUDY

Authors


Anorexia Nervosa Unit University Psychiatric Centre St. Jozef Leuvensesteenweg 517 B-3070 Kortenberg Belgium

Abstract

Eighteen female inpatients were included in a double-blind placebo-controlled cross-over study aimed at testing the hypothesis that dopamine blockade may enhance the effectiveness of behavior therapy in the short-term weight restoration of anorexia nervosa patients. The patients were given a uniform contingency management program and, after a baseline period, they alternatingly (3- week periods) received pirnozide (4 or 6 mg) or a placebo. During the first two periods pimozide almost significantly enhanced the weight gain induced by the behavior therapy program and beneficially influenced the patients attitude towards treatment.

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