Prediction of affective psychoses response to lithium prophylaxis
The role of socio-demographic, clinical, psychological and biological variables
Article first published online: 23 AUG 2007
Acta Psychiatrica Scandinavica
Volume 69, Issue 1, pages 37–44, January 1984
How to Cite
Maj, M., Del Vecchio, M., Starace, F., Pirozzi, R. and Kemali, D. (1984), Prediction of affective psychoses response to lithium prophylaxis. Acta Psychiatrica Scandinavica, 69: 37–44. doi: 10.1111/j.1600-0447.1984.tb04514.x
- Issue published online: 23 AUG 2007
- Article first published online: 23 AUG 2007
- Received June 4, 1983; accepted for publication August 5, 1983
- affective psychoses;
- prediction of response;
- lithium ratio;
- HLA antigens;
- Eysenck questionnaire.
ABSTRACT: A set of socio-demographic, clinical, psychological and biological variables was examined in 100 patients diagnosed according to Perris as bipolar affective psychotics or unipolar depressive psychotics, maintained on prophylactic lithium for 2 years and divided into responders and non-responders to this treatment on the basis of strict criteria. The results confirmed the potential role of four indices as predictors of response to prophylaxis: a positive family history of bipolar affective illness and a high red blood cell/plasma lithium ratio (positive predictors) and the presence of the HLA-A3 antigen and a high score on the Neuroticism Scale of the Eysenck Personality Questionnaire (negative predictors). A stepwise discriminant analysis showed that neuroticism score, lithium ratio and HLA-A3 antigen, taken together, correctly classified 74.6% of responders and 68.3% of non-responders. It is hypothesized that these variables as a group may be of practical value in predicting response to lithium prophylaxis, and that pharmacogenetic and, perhaps, personality factors may be involved in treatment failures.