Current outcome in schizophrenia: women vs men


*Prof. Mary V. Seeman, M.D., F.R.C.P.(C) Department of Psychiatry Mount Sinai Hospital 600 University Avenue Toronto, Ontario M5G 1X5 Canada


ABSTRACT: This article reviews the 1980's literature on gender differences in schizophrenia outcome. Neuroleptic response, long-term course, and housing, appear to be superior in women. Mortality ratios are advantageous to schizophrenic men. After menopause, women may require higher neuroleptic doses than men and are more at risk for severe tardive dyskinesia. The antidopaminergic effects of estrogens appear to be responsible for some of the outcome differences.