Imipramine binding in depression and other psychiatric conditions


9, Blegdamsvej DK-2100 Copenhagen 0 Erling T Mellerup Psychochemistry Institute Rigshospitalet Denmark


30 studies of platelet 3H-imipramine binding in depressed patients are reviewed. 19 of these studies found that depressed patients had lower binding than control persons, whereas 11 studies found no difference. This discrepancy is discussed and it is concluded that methodological problems may account for a substantial part of the low imipramine binding in depressed patients.