Is depression related to subsequent diabetes mellitus?

Authors


Marjan van den Akker, Department of General Practice Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.
Tel.: +31 43 388 2321; E-mail: marjan.vandenakker@hag.unimaas.nl

Abstract

Objective:  To compare the risk of developing diabetes mellitus (DM) in the general population between subjects who had a depression and subjects who never had a depression.

Method: Retrospective cohort design. People with depression were diagnosed with a depression between 1975 and 1990; controls never had a depression. Both groups were followed for a diagnosis of type II diabetes until 2000. Data on 1334 depressed and 66 670 non-depressed subjects were available from a large general practice-based database.

Results:  No overall relation was found, but among males below age 50 there was a 78% increase in the rate of development of DM compared with non-depressed patients (hazard ratio 1.78, 95% CI: 1.21–2.62).

Conclusion:  Depression in males between the age of 20 and 50 years is related to an increased risk of developing DM.

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