Prediction of mortality at age 40 in Danish males at high and low risk for alcoholism
Article first published online: 27 SEP 2004
Acta Psychiatrica Scandinavica
Volume 110, Issue 6, pages 476–482, December 2004
How to Cite
Knop, J., Penick, E. C., L. Mortensen, E., Nickel, E. J., Gabrielli, W. F., Jensen, P. and Mednick, S. A. (2004), Prediction of mortality at age 40 in Danish males at high and low risk for alcoholism. Acta Psychiatrica Scandinavica, 110: 476–482. doi: 10.1111/j.1600-0447.2004.00393.x
- Issue published online: 27 SEP 2004
- Article first published online: 27 SEP 2004
- Accepted for publication May 24, 2004
Objective: This prospective high-risk study examined the influence of father's alcoholism and other archival-generated measures on premature death.
Method: Sons of alcoholic fathers (n = 223) and sons of non-alcoholic fathers (n = 106) have been studied from birth to age 40. Archival predictors of premature death included father's alcoholism, childhood developmental data, and diagnostic information obtained from the Psychiatric Register and alcoholism clinics.
Results: By age 40, 21 of the 329 subjects had died (6.4%), a rate that is more than two times greater than expected. Sons of alcoholic fathers were not more likely to die by age 40. Premature death was associated with physical immaturity at 1-year of age and psychiatric/alcoholism treatment. No significant interactions were found between risk and archival measures.
Conclusion: Genetic vulnerability did not independently predict death at age 40. Death was associated with developmental immaturities and treatment for a psychiatric and/or substance abuse problem.