Neuropsychiatric disturbances in Parkinson's disease clusters in five groups with different prevalence of dementia
Article first published online: 24 MAY 2005
Acta Psychiatrica Scandinavica
Volume 112, Issue 3, pages 201–207, September 2005
How to Cite
Bronnick, K., Aarsland, D. and Larsen, J. P. (2005), Neuropsychiatric disturbances in Parkinson's disease clusters in five groups with different prevalence of dementia. Acta Psychiatrica Scandinavica, 112: 201–207. doi: 10.1111/j.1600-0447.2005.00562.x
- Issue published online: 2 JUN 2005
- Article first published online: 24 MAY 2005
- Accepted for publication April 8, 2005
- Parkinson's disease;
Objective: To investigate the inter-relationship of neuropsychiatric disturbances in Parkinson's disease (PD) by cluster analysis and describe the properties of the clusters.
Method: A total of 139 patients were assessed using the neuropsychiatric inventory (NPI). A cluster-analysis was used to investigate the inter-relationship of NPI items. The clusters were profiled regarding dementia (PDD) and major depression.
Results: A total of 39 patients showed no neuropsychiatric symptoms. The remaining 100 patients (43% PDD) were divided in to five clusters. The largest group (42, 31% PDD) showed symptoms of mild depression, followed by a group (29, 79.3% PDD) with hallucinations and mild other symptoms. The third group (14, 7.1% PDD) had sleep disturbances exclusively. The fourth group (8, 25% PDD) showed apathy, anxiety and depression. The smallest group (7, 57.1% PDD) had high scores on several NPI items.
Conclusion: Our PD sample can be divided in to clusters based on the NPI, with different prevalence of dementia and depression.