One-year outcome with antidepressant – treatment of bipolar depression
Article first published online: 1 JUL 2005
Acta Psychiatrica Scandinavica
Volume 112, Issue 2, pages 105–109, August 2005
How to Cite
Joffe, R. T., MacQueen, G. M., Marriott, M. and Young, L. T. (2005), One-year outcome with antidepressant – treatment of bipolar depression. Acta Psychiatrica Scandinavica, 112: 105–109. doi: 10.1111/j.1600-0447.2005.00583.x
- Issue published online: 1 JUL 2005
- Article first published online: 1 JUL 2005
- Accepted for publication May 20, 2005
- bipolar disorder;
Objective: To examine the risk of relapse into mania or depression with varying duration of antidepressant treatment in a cohort of 59 patients with bipolar disorder.
Method: An open naturalistic evaluation using life charting methods of patients with 1 year follow-up, who responded to antidepressant treatment and who then less or more than 6 months of antidepressant treatment.
Results: Patients who received more than 6 months of antidepressant treatment were less likely to relapse into depression at follow-up of 1 year. There was no difference in relapse rates for mania in the different antidepressant treatment duration groups. Gender and bipolar subtype did not significantly affect relapse rates for depression or mania.
Conclusion: Our data, taken with other studies, suggest that the duration of optimal antidepressant treatment in bipolar disorder must be further evaluated.