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Homocysteine levels and glucose metabolism in non-obese, non-diabetic chronic schizophrenia


David C. Henderson, Freedom Trail Clinic, 25 Staniford Street, Boston, MA 02114, USA.


Objective:  We studied a sample of schizophrenia out-patients to test the hypotheses that serum homocysteine concentrations would correlate positively with measures of glucose metabolism.

Method:  Subjects underwent a nutritional assessment and fasting plasma, serum insulin and homocysteine tests.

Results:  Males had a significantly higher homocysteine levels than females (7.69 ± 1.42 μm vs. 6.63 ± 1.40 μm; P = 0.02). Comparing subjects with normal fasting glucose (NFG) (glucose <100 mg/dl) and impaired fasting glucose (IFG) (≥100 mg/dl) subjects with IFG (mean 8.2 ± 1.5 μm) had significantly higher homocysteine levels than those with NFG (mean 7.2 ± 1.4 μm, P = 0.03). IFG was also associated with greater mean values for a Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) (P = 0.002) and diastolic blood pressure (P = 0.045).

Conclusion:  The group with IFG had higher fasting serum homocysteine concentrations than those with NFG which supports a connection to an important cardiovascular risk factor.