Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population
Article first published online: 6 OCT 2005
Acta Psychiatrica Scandinavica
Volume 113, Issue 4, pages 314–321, April 2006
How to Cite
Walss-Bass, C., Raventos, H., Montero, A. P., Armas, R., Dassori, A., Contreras, S., Liu, W., Medina, R., Levinson, D. F., Pereira, M., Leach, R. J., Almasy, L. and Escamilla, M. A. (2006), Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population. Acta Psychiatrica Scandinavica, 113: 314–321. doi: 10.1111/j.1600-0447.2005.00631.x
- Issue published online: 6 OCT 2005
- Article first published online: 6 OCT 2005
- Accepted for publication July 19 2005
- linkage disequilibrium
Objective: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia.
Method: Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland.
Results: The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P-value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over-transmitted to persons with a history of manic psychosis.
Conclusion: These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings.